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Dr. Martin Pomper

Dr. Pomper was born in Chicago, Illinois and attended college at the University of Illinois at Urbana-Champaign, majoring in biochemistry and chemistry. Also at Illinois, in the context of the Medical Scholars Program, he earned M.D. and Ph.D. degrees, the latter in organic chemistry. All of his postgraduate medical training was undertaken at the Johns Hopkins Medical School, which included an internship in medicine (Osler Service), residencies in radiology and nuclear medicine, and a neuroradiology fellowship. He is currently professor in the Neuroradiology Division of the Department of Radiology. His research interests involve molecular imaging, particularly of central nervous system processes and cancer.

Dr. Pomper is the director of the Small Animal Imaging Resource Program (SAIRP, http://www.hopkinsradiology.org/sairp), Co-Director of the Johns Hopkins Center for Cancer Nanotechnology Excellence (CCNE, http://ccne.inbt.jhu.edu/), Co-Director of Positron Emission Tomography (PET, http://pet.rad.jhmi.edu/) at Johns Hopkins and Associate Director of the In Vivo Cellular and Molecular Imaging Center (ICMIC, http://icmic.rad.jhmi.edu/). He is also the Director of the Center for Translational Molecular Imaging (CTMI) on the Johns Hopkins Bayview Campus.

Specific research projects in central nervous system imaging include (a) using PET and advanced magnetic resonance spectroscopy (MRS) techniques to uncover brain metabolic correlates of AIDS dementia; (b) using PET to study molecular (neurotransmitter) and cellular abnormalities in patients with AIDS dementia; and (c) the development of new radiopharmaceuticals for imaging nicotinic and glutamatergic neurotransmission as well as for imaging inflammation. In oncology, advanced magnetic resonance imaging (MRI) techniques, such as diffusion tensor and amide proton transfer imaging are being used to study brain tumors. In addition, radiopharmaceutical and optical imaging agents are being developed to study prostate cancer, metastatic potential, infection, inflammation and to study the pharmacokinetics of chemotherapeutic agents in vivo. Molecular-genetic imaging of cancer is another priority.

His research group consists of chemists, physicists, molecular biologists and clinicians working together toward clinical molecular imaging. He is Editor-in-Chief of Molecular Imaging and a past President of the Society of Nuclear Medicine’s Molecular Imaging Center of Excellence. He has numerous patents related to medical imaging, many of which have been licensed, as well as several imaging agents in clinical trials.

Recent publications:

Bhang H-E, Gabrielson KL, Laterra J, Fisher PB, Pomper MG. Tumor-Specific Imaging through Progression Elevated Gene-3 Promoter-Driven Gene Expression. Nat Med 2011, 17:123-129.

Lentz MR, Degaonkar M, Mohamed MA, Kim H, Conant K, Halpern EF, Sacktor N, Barker PB, Pomper MG. Relationships between macrophage colony stimulating factor levels, neuroaxonal metabolism and cognition during chronic HIV-infection. J Neurovirol 2010, 16:368-376.

Banerjee SR, Pullambhatla M, Byun Y, Nimmagadda S, Green G, Fox JJ, Horti A, Mease RC, Pomper MG. 68Ga-labeled inhibitors of prostate-specific membrane antigen (PSMA) for imaging prostate cancer. J Med Chem 2010, 53:5333-5341.

Nimmagadda S, Pullambhatla M, Stone K, Green G, Bhujwalla ZM, Pomper MG. Molecular imaging of CXCR4 receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography. Cancer Res 2010 15; 70:3935-3944.

Hammoud DA, Endres CJ, Hammond E, Uzuner O, Brown A, Nath A, Kaplin AI, Pomper MG. Imaging Serotonergic Transmission with [11C]DASB-PET in Depressed and Non-Depressed Patients Infected with HIV. Neuroimage 2010; 49:2588-2595.

Martin G. Pomper, M.D., Ph.D.
Professor, Departments of Radiology, Pharmacology, Oncology, Radiation Oncology, Psychology and Environmental Health Sciences in the School of Public Health
Division of Neuroradiology
Johns Hopkins Medical School
492 Cancer Research Building II
Baltimore, MD 21287
410/955-2789 (office)
443/817-0990 (fax)

Dr. Pomper also has an appointment in the Department of Pharmacology and Molecular Sciences: http://www.hopkinsmedicine.org/pharmacology_molecular_sciences/faculty/bios/pomper.htmll


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